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Feel Good Biochemistry is a book that allows you to take control and chart your own path to health and wellness. An ideal starting point for testing is to run a Hair Elements Analysis. I abbreviate this test to the acronym HMT. The HMT gives you a sense of the long term status of both toxic and essential minerals in your body. While the urine and ….
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Serine-rich splicing factor 3 SRSF3 plays a critical role in liver function and its loss promotes chronic liver damage and regeneration. As a consequence, genetic deletion of SRSF3 in hepatocytes caused progressive liver disease and ultimately led to hepatocellular carcinoma. We showed that palmitic acid—induced oxidative stress caused conjugation of the ubiquitin-like NEDD8 protein to SRSF3 and proteasome-mediated degradation. Lastly, prevention of SRSF3 degradation in vivo partially protected mice from hepatic steatosis, fibrosis, and inflammation. These results highlight a neddylation-dependent mechanism regulating gene expression in the liver that is disrupted in early metabolic liver disease and may contribute to the progression to NASH, cirrhosis, and ultimately hepatocellular carcinoma. The molecular underpinnings of interleukin-6 IL-6 blockade—refractory patients remain unknown; no targeted therapies exist.
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The laboratory includes biochemical tumor markers, pharmacology-pharmacokinetics and molecular oncology activities, and develops research programs. The pharmacology laboratory handles therapeutic monitoring activities and has a support function for the regional and national research teams. Pharmacology is a scientific speciality that studies the mechanisms of interaction between an active substance such as a drug molecule and the body in which it is active.
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